Background: Although it has been demonstrated that malaria, which causes a significant number of deaths in endemic countries, affects hematological parameters both directly and indirectly, certain hematological parameters among populations in malaria-endemic regions have not been consistently described as a standard for measuring malaria burden. A feverish condition with several blood cell parameter changes is caused by malaria. Among these alterations are anemia and thrombocytopenia. Objective: The objective is to assess the evaluation of Hematological Changes in Malaria Patients in Shendi Town, Sudan. Methodology: The study was conducted across sections. This study included 80 people, of which 30 were healthy for comparison and 50 had malaria. Each person who gave informed consent to participate in the study had approximately 5 milliliters of blood drawn. A complete blood count was carried out on their samples using a hematology auto-analyzer to ascertain their hematological parameters. The Statistical Package for Social Sciences (SPSS) version 23 was used to statistically evaluate the data collected from the study after it was entered into a database. Results: According to the study, the average age of the malaria patients was 29.8 years, with 48% of them being men and 52% being women. The mean values of Hb, PCV, RBCs, MCV, MCH, MCHC, and RDW were (11.2 g/dl), (33.5%), (4.1x1012/l), (80.7 fl), (42.3 pg), (33.0 g/dl), and (17.8), respectively, according to the complete blood count (CBC). The mean TWBCs, neutrophils, lymphocytes, mid-platelet count, and MPV were also higher, at 6.5 x 109 /l, 60.2%, 29.9%, 9.4%, 206.1 x 109 /l, and 8.7 x 109. Conclusion: Significant alterations in hemoglobin, packed cell volume, platelets, and neutrophils are caused by malaria.