Wound infection is a significant health problem in many parts of the world especially, Africa. It complicates the recovery of the patient, increases trauma care, prolongs hospital stay and has economic consequences on the patient. This study was aimed to isolate, Identify and determine the antibiotic susceptibility profile of some bacteria associated with deterioration of infected wound in Kano State, Northern Nigeria. The study involved 170 patients attending Murtala Muhammad Specialist Hospital Kano for treatment of infected wound. Isolation and identification of the isolates was conducted using standard microbiological techniques. The bacteria isolates were subjected to antibiotic susceptibility testing using the agar disk diffusion method. The results showed that total of 6 different species were identified. S. aureus has the highest frequency with total of occurrence 90 (26.9%), followed by Pseudomonas with total frequency of 66 representing (20.3%), then E. coli with frequency of 54 (16.1%). Klebsiella, S. epidermidis and Proteus spp has percentage occurrence of 15.2%, 12.5% and 09.0% respectively. Generally, antibiotic resistivity of isolates to commonly used antibiotics was low; the results showed that 15 out of 355 isolates were multidrug resistant representing 4.5%. Ciprofloxacin, Augmentin and Gentamycin. It is concluded that several bacteria were responsible for wound infection.