The management of acute appendicitis involves performing an appendectomy, which can be done as an open or laparoscopic method. Since its introduction, laparoscopic appendectomy has been performed for both uncomplicated and complicated appendicitis. Laparoscopic appendectomy is minimally invasive and associated with reduced postoperative complications, early ambulation, and faster recovery. Single incision laparoscopic appendectomy and natural orifice transluminal appendectomy are newer variants of minimally invasive surgery that are being performed for acute appendicitis. In this review, we will investigate the role of laparoscopic appendectomy, single incision laparoscopic appendectomy, and natural orifice transluminal appendectomy in the management of acute appendicitis.