Acalypha indica has long been valued in traditional medicine, yet its potential in managing obesity and diabetes remains inadequately explored. This study aims to evaluate the pharmacognostic features and anti-obesity potential of Acalypha indica extracts obtained through ultrasound-assisted extraction (UAE). The extraction process was optimized using UAE to maximize the yield of bioactive constituents. Phytochemical profiling was conducted to assess total phenolic and flavonoid content. The anti-obesity activity was evaluated through in vitro pancreatic lipase and HMG-CoA reductase inhibition assays. Molecular docking and network pharmacology analyses revealed that key compounds such as Element, Anthraquinone, and Cholesterol interact with pivotal metabolic targets including NOS3, STAT3, and EGFR. The compound-target-pathway network illustrated a polypharmacological mode of action, where multiple bioactive synergistically regulate obesity-related pathways such as the Apelin signalling and progesterone- mediated oocyte maturation. Acalypha indica exhibits promising anti-obesity activity through dual enzyme inhibition and multi-target modulation of metabolic pathways. These findings support its therapeutic potential as a natural intervention in obesity management. Further in vivo and clinical validations are recommended to substantiate its efficacy and safety.