Men use aphrodisiac substances during sex for a mix of psychological, physiological, social, and cultural reasons. Using aphrodisiac substances whether herbal, pharmaceutical, or recreational—can affect male psychological health in several ways. These effects depend on frequency of use, underlying health conditions, expectations about sexual performance, and the type of substance used. Many men may begin to believe that sexual performance is impossible without the substance and his can lead to: decreased natural sexual confidence, reliance on external aids and anxiety about sexual failure if the substance is unavailable. This psychological dependency can be as impactful as physical addiction. This study is aim to evaluate the Psychological Factors Associated with the Frequent Use of Aphrodisiacs During Sexual Activity Among Men in South-South Nigeria. This was a cross-sectional study involving 250 women. A well-structured questionnaire was administered to participants. The study lasted for a period of 2 months. Statistical analysis was done using SPSS version 25.0 and p < 0.05 was significant. The results revealed that 75% of the participants were addicted to the use of aphrodisiac substance, 64% had anxiety, 72% were ashamed of constant erection, 68% were confused, 76% were depressed, 86% isolated themselves.