Cordia myxa L is one of the medicinal plants that are applicable in the treatment of many diseases. In many studies, the anti-inflammatory, antifungal, properties of C. myxa have been proven. This study was concerned with the active components and therapeutic effects of C. myxa. Results indicated the presence of the following functional groups alkenes, alkyl halides, aromatics (873.75, 956.69, 1018.41, and 1417.68). The antifungal action of ethyl acetate, ethanol of Cordia myxa extract, fluconazole (FCZ) (standard), and amphotericin B (AmB) (standard) against three fungi and yeast was assessed at the same time (17.08±0.40, 26.00±0.50, 32.59±0.59, and 28.12±0.57) and (25.00±0.46). The activity of the metabolites of Cordia myxa was very high (26.00±0.50) against Cladosporium herbarum. To determine the impact of the oral administration of Cordia myxa extract on the serum enzymes, experimental testing was done in vitro on laboratory rats. Their findings demonstrated that (75.00±3.94, 88.09±4.57, and 24.06±2.03) of Cordia myxa methanol extract, and (121.09±7.01, 150.00±8.37, and 40.00±2.09) of using Di-(2-ethylhexyl)-phthalate, and (43.00±3.06, 60.51±2.68 and 20.94±1.73).