Stroke is a leading cause of long-term disability that greatly affects patients’ quality of life. Sociodemographic factors and psychological aspects, such as coping strategies and anxiety, are important determinants of quality of life among post-stroke patients. This study aimed to examine the relationship between sociodemographic characteristics, coping strategies, and anxiety levels with the quality of life of post-stroke patients. This study used a quantitative cross-sectional design. A total of 89 post-stroke patients were recruited through purposive sampling. Data were collected via questionnaires covering respondent characteristics, coping, anxiety levels, and quality of life. The data were analyzed using both bivariate and multivariate statistical tests. The results showed that age and education level were significantly linked to quality of life (p < 0.05), while gender, marital status, employment status, and duration of stroke were not significantly linked (p > 0.05). Coping and anxiety levels were significantly associated with quality of life (p < 0.001), with anxiety identified as the most influential factor. The quality of life for post-stroke patients is affected by both sociodemographic and psychological factors, especially coping mechanisms and anxiety. Nursing interventions should focus on a holistic approach by improving adaptive coping skills and managing anxiety to enhance patients’ quality of life.