Background: Research on allergy disease has focused a lot of emphasis on pet exposure as a possible risk or protective factor. The prevalence in owning pets, especially dogs, cats, and birds, has significantly increased in recent decades. This study's goal was to look at any possible effects that pet exposure might have on IgE levels. Methodology: A total of 60 participants were enrolled, including 15 healthy controls who had no contact with any pets (neither birds nor cats). Pet owners made up the remaining 45 subjects (exposed to pets). The fluorecare system measures total IgE. Results: The results of this study showed that the median concentrations of total IgE were significantly higher (p≤0.05) in pet-exposed individuals (168.40 IU/mL; IQR: 41.5-112) than in the non-pet-exposed group (44.50 IU/mL; IQR: 34-64.50). Group 1 (one pet owner) had the lowest total IgE concentrations among the three groups, with a median of 89.20 IU/mL (IQR: 17.47–128.41), and group 1 (cat owner) had the lowest median level of IgE, 134.06 IU/mL (29.12-405), despite the data showing a statistically significant difference (p≤0.05) in total IgE concentrations among the groups based on the number of pets. Conclusion: The kind of pet exposure plays a major role in determining IgE concentrations. This implies that there is an additive effect of allergens on sensitization to the allergens, thus resulting in higher allergic sensitization.