Aquatic plants exhibit the ability to bioaccumulate heavy metals, including cadmium and lead. However, the various physiological effects have not been studied in detail. Therefore, the current study aims to investigate the effects of cadmium chloride and lead chloride on the physiological status of Ceratophyllum submersum and Ceratophyllum demersum. The results of the study showed the effect of different heavy metal concentrations on the physiological state of the studied aquatic plants, Ceratophyllum submersum and Ceratophyllum demersum. There was a decrease in chlorophyll concentration and protein concentration in aquatic plants compared to the control group exposed to heavy metal concentrations. The study concludes that heavy metals affect the phylogenetic state of the plants Ceratophyllum submersum and Ceratophyllum demersum through loss of pigmentation, oxidative stress responses, or enzymatic changes. The current study aims to investigate the effects of cadmium chloride and lead chloride on the physiological status of Ceratophyllum submersum and Ceratophyllum demersum.