Any thyroid dysfunction has broad systemic effects, extending beyond mere hormonal imbalances to include inflammatory and immune responses. This study aimed to assess thyroid hormons and C-reactive proteins (CRP) in patients with hyperthyroidism and hypothyroidism, comparing them to a control group of healthy individuals. Materials and methods: This study was conducted between June and October 2025, and included 90 participants (30 with hyperthyroidism, 30 with hypothyroidism, and 30 healthy individuals as a control group). The results showed significant differences in thyroid hormone levels between the two patient groups and the control group. Hyperthyroid patients showed a marked decrease in T3 and T4 levels (p < 0.001). While decrease in hypothyroidism patients. CRP levels were significantly higher in both hyperthyroid (27.87 ± 22.12 mg/dL) and hypothyroid (24.06 ± 23.08 mg/dL) patients as compared to the control group (0.38 ± 0.52 mg/dL). Conclusion: The present study concluded increase T4, T3 in hyperthyroid patients, while decrease in hypothyroidism patients. CRP levels were significantly higher in both hyperthyroid and hypothyroid patients as compared to the control group.