Malaria is a devastating disease affecting millions of lives in tropical and subtropical countries since ages. Despite significant reduction in malaria cases since 2010, malaria continues to be one of the major infectious diseases. Malaria elimination efforts are hampered with the emergence of multidrug resistant strains. The most promising vaccine candidate against malaria is RTS,S that showed an efficacy of 39-50%. The development of efficient vaccine remains elusive because of parasite multistage life cycle and antigenic variation. Global efforts are underway to eradicate malaria and there is significant progress in fight against malaria with many countries certified malaria free during last five years. The recent addition to this list is Algeria and Argentina and China is heading forward to be malaria free with no indigenous malaria case. However, rapid development of drug resistance strains highlights requirements of more efforts to defeat the pathogen.