The Corona virus disease 2019 is an infectious viral disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS -CoV2). It is characterized by cough, fever, breathlessness, sore throat and sometimes fatigueness. Research has played a vital and efficient role in discovering the etiopathogenesis of the diseases. The various pharmaceutical and biomedical approaches of research investment along with its overall growth have been increased efficiently over the past decades. The various research approaches against COVID-19 have been taken into consideration. The spike protein feature of the Virus is utilized by the Researchers to predict the risk of infection and to monitor the phylogenetic and evolutionary dynamic related to corona virus.In order to view the mechanism of attachment of corona virus at molecular level to various oligosaccharide, researchers have revealed that the cryo-EM entities of coronavirus known as OC43 S(a type of trimer of glycoprotein) in isolated and in associated form 9-O-acetylated sialic acid. In the relay of development of the effective therapeutics that possess the power to block viral entry, Mr. Genwei from the Pentelute’s lab had executed the computational novel simulations involving the associations amongst the ACE2 receptor and the receptor binding domain of the corona virus which was having the spike like protein. Many efficient drugs and vaccines are in development phase like Fusogenix DNA vaccine, AdCOVID and various others have surpassed the clinical trial such as Moderna's RNA Vaccine, Chinese Can Sino Biologics Inc Vaccine etc. COVID- 19 has also a challenging issue for scientist and researchers. Its mutational rate ,gene specificity and adaptability towards host is unique features through which its existence is highly potential, Medical sciences ,Biotechnology, Bioinformatics, Social sciences etc. all are doing golden handshake to bring more and more research opportunities to serve in the benefit of human kind. High throughput data generated by Next Generation Sequencing is opening a new door to find out the novel targets, miRNA identification and effective therapeutics against COVID-19. Therefore the article summarizes the significant contribution of research in this pandemic and how this is benefiting the mankind.