Thrombophilia causes venous thrombosis predominantly, sometimes arterial thrombosis in susceptible individuals causing increased morbidity and mortality. Cerebral venous thrombosis (CVT) is the commonest complication resulting from thrombophilia in young patients that can lead to diagnostic confusion. The treatment is either replacement therapy with prothrombotic factors that are deficient or anti coagulants if CVT occurs. Here we present some interesting three cases of CVT admitted and treated in a tertiary care hospital in South India.