In line with the fundamental responsibilities of a nurse to promote health, prevent illness, restore health and to alleviate suffering, advanced practice nursing roles are developing globally to provide expert nursing care at an advanced level of practice though these are not without challenges to the practice. In Nigeria, advanced practice nursing is still evolving and for the practice to be effectively and successfully adopted, the many challenges and limitations to nursing practice in the country need to be identified and solutions proffered. This paper seeks to explain the concept of Advanced Nursing practice, the global practice taking into cognizance the challenges/barriers to the practice and the strategies adopted to overcome these barriers. Also the challenges to the practice in Nigeria will also be discussed and possible ways forward recommended.