Introduction: Digoxin is an inotropic drug indicated for Congestive Heart Failure (CHF) and cardiac arrhythmias. It has a narrow therapeutic index. Predisposing factors and drug-drug interactions causes digoxin toxicity at normal therapeutic doses. Hence we report a case on the adverse drug reaction of digoxin induced sinus bradycardia due to the co-administration of amiodarone with digoxin. Case report: An 83years old female patient with the known case of paroxysmal atrial fibrillation and heart failure with preserved ejection fraction. She is a known case of type 2 diabetes mellitus and hypertension. She was on treatment with digoxin (0.25mg) 5 days in a week along with amiodarone 200mg BD and other drugs. With ECG report indicating sinus bradycardia and the laboratory investigations the physician’s diagnosis as an ADR caused by the drug-drug interaction resulting from the concomitant use of digoxin and amiodarone. Causality assessment was done and the drugs were withdrawn from the drug regimen. After which the patient improved symptomatically. Discussion: Sinus bradycardia is one of the early signs of digoxin toxicity. The drug interaction with amiodarone which has the potency to increase the digoxin concentration must be considered and individualization of medicines in such cases is of prime importance in order to avoid the undesired side effects or toxicity. Conclusion: Low margin of safety drug like digoxin should be prescribed with the consideration of all aspects pertaining to the individual patient. Monitoring for drug-drug interactions and also periodic Therapeutic Drug Monitoring (TDM) is beneficial.