This study evaluated the influence of combined application of cattle dung and NPK fertilizer (NPK 15 -15 -15) on soil physicochemical properties, growth, nutrient uptake and yield of fluted pumpkin (Telfairia occidentalis) during the dry season of 2015. The pot experiment was conducted at Faculty of Agriculture Complex, Kogi State University, Anyigba in a Completely Randomized Design (CRD) with seven treatments and four replicates. The treatments were 250 kg/ha NPK fertilizer, 2 t/ha cow dung, 2 t/ha cow dung + 250 kg/ha NPK fertilizer, 3 t/ha cow dung + 300 kg NPK fertilizer, 4 t/ha cow dung + 350 kg NPK fertilizer, 5 t/ha cow dung + 400 kg NPK fertilizer and a control. The following growth and yield parameters were measured; average number of leaves, branches, stem girth and internode length. Results from this study showed that combined application of cow dung and NPK fertilizer significantly (P < 0.05) increased organic carbon, available P, soil pH, total nitrogen, exchangeable bases and Effective Cation Exchange Capacity compared to the control. The amendments did not significantly influence soil physical properties. Uptake of N, P, K, Ca and Mg were higher with treatments in which cow dung was combined with NPK fertilizer compared to the control. It was observed that all growth parameters increased with increased levels of nutrient application. The growth parameters were high in pots treated with high rate combinations of organic and inorganic fertilizer and significantly different from either sole organic or inorganic nutrient sources or control. The results suggest that, application of 5 t/ha cow dung + 400 kg/ha NPK fertilizer is recommended for fluted pumpkin production in Anyigba, but in terms of economic and environmental considerations, the application of 5 t/ha of cow dung+250 kg/ha NPK is recommended.