The effect of Indocid® was determined using thirty (30) albino rats of mixed sex, aged 3 months weighing 110-200g. They were acclimatized to their environment for 2 weeks during which they were fed with standard pelleted feed and water. The study is divided into acute toxicity testing and main experimental phase. The acute toxicity testing for the determination of the median lethal dose was ascertained using 12 rats divided into groups K, L, M. The main experiment using 18 rats divided into groups A, B, C, D, E and F of three (3) rats in a group in different cages, cage A served as control. The rats were orally administered graded doses of Indocid dissolved in water once daily along with their feed for 30 days. Cages B-F received 3.0, 2.5, 2.0, 1.5 and 1.0 mg/kg respectively and were closely observed. At day 31, the rats were randomly selected, sacrificed, the stomach, and small intestine were excised, examined grossly and subsequently processed for light microscopy. Grossly the organs and tissue appeared to have several perforations especially evident in the small intestine. Further histological examination revealed erosion of the stomach and intestine. This result forms the basis for further research into the danger posed to indiscriminate users of Indocid®.