Aim: This study aimed to mechanically test the shear bond strength (SBS) of cobalt-chromium (Co-Cr) metal frameworks prepared with three different production techniques with dental porcelain after the thermocycling process. Materials and Methods: Sixty Co-Cr-based metal substructure samples were prepared using traditional casting, CAD/CAM system, and laser sintering methods. The samples were treated with uniform layering porcelain and half of the subgroups (n=10) were thermocycling (5000 cycles, 5–55oC). Metal-ceramic bond strength of all samples was evaluated using the shear bond test under the standard. The shear bond strength values to the normal distribution was examined with an analysis program (SPSS for Windows 22.0, Chicago, IL, USA) was used for statistical analysis of the obtained data. One-way ANOVA test and post hoc test (Tukey’s) performed for data evaluation. Results: A statistically significant difference was observed between the average bond strength (MPa) in the comparison of different production techniques (p˂0.05). The average bonding strength of the samples grouped according to different fabrication methods; was found 16.54 ± 2.42 MPa for the CAD/CAM milling method, 8.98 ± 4.16 MPa for selective laser sintering, and 8.76 ± 3.05 MPa for conventional casting. When comparing the thermocycling application of the prepared samples, a statistically significant difference was found between the means of shear bond strength. The CAD/CAM milling group has the highest value (15.54 ± 2.16) and is statistically different from the others. Conclusions: According to the results of this study, it was determined that the production method affects the metal-ceramic bond strength, but the thermocycling application does not make a significant difference. Milled Co-Cr samples had a higher SBS value than casting and laser sintering samples.