This study was conducted during July to October 2017, in the White Nile at Khartoum state, to determine the effect of industrial sanitation on plankton, the discharge come from Soba Sanitation plant, Elyarmok industrial complex and other industrial waste water to the White Nile water. The phyto and zooplankton were investigated under microscope in the laboratory of agriculture. Phytoplankton green algae were dominant in location A with species Ulothrix (27%), and location with species Oedogonium (34%), in locations C and D. Blue- Green algae was dominant with species Spirrolina (31%). Zooplankton, Rotifers in site a (26%), site B (10%), site C (5%) and site D (21%). Crustacean in site A (57%), site B (52%), site C (5%), and site D (37%). This study concluded that the direct disposal of sewage and industrial effluent in the White Nile degrade its water quality and planktonic biodiversity.