This is a review paper focusing on the acquisition of entrepreneurial skills in science through the authentic learning strategy to solve the youth unemployment problem in Nigeria. The youth unemployment in Nigeria is observed to be on the increase as indicated by statistics, and the various interventions seem not to be yielding significant results. It is on this background that the paper suggests the entrepreneurial skills through the authentic learning paradigm in Nigeria. The authors asserted that entrepreneurial skills are critical to job creation and self-employability because it enhances creativity and critical thinking skills. The authentic learning is a learning model that connects what the students learned in the classroom to the real-life, challenges and application. Some topics in science among many were identified in this thesis where students could acquire entrepreneurial skills that could make them self-employed after graduation. The paper identified some implications of the paper and make suggestions for future studies.