Severe acute respiratory syndrome coronavirus 2 infection might induce a significant and sustained lymphopenia, increasing the risk of developing opportunistic infections. We present our clinical experience with two cases of opportunistic infections with mucormycosis and actinomycosis leading to maxillary osteomyelitis in patients associated with uncontrolled diabetes mellitus in post-covid-19 status. One out of two cases had received steroid therapy during the treatment of COVID-19. Both the cases have a history of tooth extraction, following which they developed swelling over cheeks associated with nasal and intra-oral purulent discharge. On CT face, both the cases showed similar features of fungal osteomyelitis. But, when an incisional biopsy was performed, the first case revealed large, non-septate hyphae with 90° branching suggesting mucormycosis, whereas the second case showed inflammatory lesions suggestive of actinomycosis. Both the patients were later managed with oral antibiotics and planned for surgery. These cases highlight coronavirus might impair the immune response, exposing patients to a higher risk of developing opportunistic infections and hence the knowledge about the involvement of a wide spectrum of opportunistic microbes helps the surgeon in planning the surgery ranging from a more aggressive approach for fungal infections to less invasive management for bacterial infections.