Attitude is one of the key factors that influence student performance in any subject in secondary school education. Bondo has been among the Sub Counties in Kenya with poor academic performance in Chemistry subject and this could be attributed to poor student attitude towards the subject among other factors. This research paper sought to establish and address the effect of student attitude on performance in Chemistry subject in secondary schools in Bondo Sub County. The main objective of this study was based on the purpose of the study. The study was informed by Jean Piaget’s constructivism theory of knowledge and its link to the study was done by a conceptual framework. The study adopted a correlation research design. Questionnaires, interviews and document analysis were used as instruments of data analysis. Quantitative data analysis generated both inferential and descriptive statistics while qualitative data was analyzed continuously using content and thematic issues. The findings revealed that the Pearson correlation co-efficient, r = 0.078 which is a positive correlation between attitude and academic performance in the subject in over 80% of the schools.