In 1959 the British Southern Cameroons witnessed a peaceful political transition as the opposition Kamerun National Democratic Party defeated the ruling Kamerun National Congress in the general elections. As a result, J. N. Foncha took over the premiership of the territory from E.M.L. Endeley. This was the first democratic regime change in Africa south of the Sahara and it was also the first time women were granted the franchise in this British administered UN Trust Territory. Using primary and secondary data, this paper attempts an investigation into the reasons for the enfranchisement of women and the importance of the first female votes in this territory. The findings revealed that the victory of the opposition was largely determined by this newly enfranchised electorate who had a number of grievances against the incumbent regime. It can therefore be concluded that Endeley's premature political demise was the handiwork of the female electorate who were predominantly anti-Igbo and pro-reunification unlike Endeley. Women therefore contributed in no small way to Foncha's victory and this confirms the view that the female votes are always decisive in most crucial elections.