Triazines are a diverse class of compounds that possess three consecutively bonded nitrogen atoms. Triazenes have been utilized in a variety of research areas. In organic synthesis, they have been used as protecting groups for aromatic amines, as linkers in solid-phase peptide synthesis and as synthons for novel heterocyclic compounds. In the present research work, we synthesized a series of novel Benzothiazole derivatives and Triazene derivatives by using some sulfa drugs. The Benzothiazole derivatives such as substituted 2-amino benzothiazole synthesized by a different procedure in which some sulfa drugs were reacted with ammonium thiocynate and prepared substituted phenylthiourea. The cyclization of substituted phenylthiourea prepared in the presence of bromine solution with chloroform and then prepared Benzothiazole nucleus. Triazene derivatives such as substituted 4-[1(E)-3,3 dimethyl-1-triazen-1-yl] synthesized by a different procedure in which some sulfa drugs were reacted with dimethylamine in presence of 6M HCl and NaNO2 and then prepared substituted 3,3 dimethyl-1-triazen-1-yl. These compounds were screened for anti-inflammatory activity by carrageenan induced paw oedema method in rats at a dose of 10 mg/kg body weight.