South Asian Research Journal of Pharmaceutical Sciences (SARJPS)
Volume-3 | Issue-06
Review Article
Super Porous Hydrogel Based Drug Delivery System: A Review
Navneet Kumar Verma, Asheesh Kumar Singh, Vikas Yadav, Prashant Singh, Ankur Yadav, Shiwani Jaiswal
Published : Nov. 11, 2021
Abstract
Superporous hydrogels (SPHs) is originally developed as a novel drug delivery system to retain drugs in the gastric medium by instant swelling on water absorption through open porous structure and maintain their integrity in that harsh environment. These materials can be synthesized to respond to a number of physiological stimuli present in the body, such as PH, ionic strength, temperature. Hydrogels are a unique class of three dimensional cross-linked polymeric networks that can hold a large fraction of aqueous solvents and biological fluids within their structures. Nowadays, hydrogels have attracted a growing interest of many scientists in different fields of research. Intelligent hydrogels have found a significant role in a wide variety of applications such as drug delivery systems, tissue engineering, optics, diagnostics and imaging. The purpose of this paper is to present a brief review on the basis concept of hydrogels, the description about classification, synthesis methods, stimulation situations, relevant mechanisms, and applications. It also involved technologies adopted for hydrogel production together with process design implications, block diagrams, and optimized conditions of the preparation process. An innovated category of recent generations of hydrogel materials was also presented in some details. The formulations obeyed Higuchi and Korsmeyer- Peppas kinetics of drug release. For further confirmation, the data were fitted to the Kopcha model to get the evidence of drug release by the combination of diffusion-controlled and chain relaxation–swelling mechanism. However, the diffusion mechanism predominated the process leading to quasi diffusion and anomalous diffusion mechanism.