The samples of seawaters were collected during winter 2019 and summer 2020 from coasts on Red Sea at Al Hudaydah Governorate to understand the distribution of nutrients and the dynamics of the microbiological component with special reference to bacteria and find out the relationship between phsicochemical characteristics and microbiological components. The samples of nutrients (NO3-, NO2-, PO4-3, SiO4-4) were measured using spectrophotometric techniques (DR 3900, HACH, USA). The variation of the nitrates was lower during summer and higher during winter, due to the high temperature, which increases the photosynthesis process and thus the increased consumption of nitrate by phytoplankton growth. The variation of the NO2 were less in summer and high in winter due to the high temperature, which increases the photosynthesis process. Seasonally, the high levels of phosphate in summer compared to winter because the increase the household water discharges containing high concentrations of soap and detergents. Factors analysis indicates that, the strong positive loadings of PO4, TC. It is clear from the table (2), that the discharged water to the marine environment is characterized by a very high load of organic matter and coliform bacteria, and this is clear from the relationship between BOD and all the parameters.