SAR Journal of Medical Biochemistry
Volume-1 | Issue-01
Original Research Article
Detection of protein complexes in blood plasma synthesized by malignant glioma cells and their microenvironment by dynamic light scattering depending on the degree of the blood-brain barrier permeability
Gridina N.Ya, Chunikhin A.Yu, Morozov A.N, Rozumenko V.D, Draguntsova N.G, Belousova A.D, Tarasov A. L, Beloshitsky V.V
Published : Feb. 28, 2020
Abstract
In the blood plasma of patients with malignant gliomas of the brain by method dynamic light scattering protein complexes with diameter of more than 150 nm were detected, indicating increased permeability of the blood-brain / tumor (BBTB) and blood-brain (BBB) barriers. The results of these studies are taken as the basis for the development of the express method for determining the increased permeability of the BBTB and BBB in neurosurgical patients. The method can be used at a certain stage of chemotherapy for patients with malignant gliomas of the brain, depending on the permeability of the BBTB and BBB.
