Rapid transmission of corona virus throughout the globe has put many more on risk of contracting this virus so prevention & prophylaxis became an important part of this pandemic so the role of Hydroxychloroquine is being discussed here.The CDC On March 24th , both Hydroxychloroquine have in vitro activity against SARS-CoV-2, and other coronaviruses, with HCQ having higher potency against SARS-CoV-2. The drug also raised the risk of heart problems. But based on the available evidence, it has been opined that HCQ is relatively safe, when certain contraindications are avoided, and has some beneficial effect as a prophylactic option.