This work Successful Sermonic Communication in Multi-Cultural African Contexts: The Cultural Intelligence Imperative is motivated by the increase in multi-cultural churches springing up in Africa. The network of globalization, secularization, modernization and postmodernism corporate to escalate this phenomenon in the African context, as movements from the rule areas to urban centres become more increasing unstoppable. The changing face of church congregants propels Homiletics to seek means and methods of ensuring successful sermonic communication in these highbred congregations. The interplay between culture and communication constitute a challenge to effective preaching in multi-cultural contexts in Africa, the writer therefore proposed „cultural intelligence‟ as a resource for the challenge. Using the historical and descriptive research methods the writer exposes the cultural intelligence components as they serve as panacea for the described problem. The work reveals that successful sermonic communication is achievable in multi-cultural contexts as preachers develop cultural intelligence.