Islam is a complete way of life. The religion leaves nothing untouched necessary to run the affairs of human being. The desire of Almighty Allah is that every people not only will leave the world simply as a Muslim but rather as a complete Muslim. With this end in view, the Glorious Qur‟an was revealed as a source of guidance, mercy, and favor to the believers and it called in several passages the importance of the use of human intellect to reflect and understand the mercy, favor, guidance that Almighty Allah make upon his creation and if they were to be adopted, man will never be misguided and go astray. Despite the guidance sent to man, he has engaged himself in unrighteous deeds and attitudes which are contrary to the teaching of the true religion which is not exceptional among some of the Nigerian men. Therefore the research seeks to analyze critically the relevant and inter-play between reason and revelation in guiding man in modern Nigeria. Finally the research finds out that if man can truly followed the teaching and guidance sent down to him through revelation and also use his reasoning in a proper way and manner to reflect and acts over what has been revealed to him, he will never be misguided and Nigeria will be a peaceful atmosphere for him to live and worshipped his Lord without any obstacles.