The study investigated the effect of Adansonia digitata and garlic on Blood glucose level in streptozotocin induced diabetic rats. Twenty (20) albino rats were divided into four groups (GI, II, III, and IV) of five rats each and their fasting blood glucose was noted prior to inducement with diabetes using streptozotocin (STZ) at dose of 50mg/kg body weight. GI serves as diabetic control, receives no extract, while GII, GIII and GIV were respectively administered with 500mg/Kg Adansonia digitata extract, 400mg/Kg garlic extract and 500mg/Kg Adansonia – Garlic premix orally for 12 days. The serum blood glucose was monitored at interval of three days, after which the rats were allowed for nine days without extract with periodic record of their blood glucose at interval of three days. The fasting blood glucose in each group 24 hours after streptozotocin (STZ) injection was significantly higher (P<0.05) when compared Zero hours (before induction). The periodic Blood glucose levels were significantly lower (P<0.001) in the Group treated with 500mg/kg of Adansonia digitata, 400mg/kg of garlic and 500mg/kg of the premix extract compared to the corresponding period of GI. On withdrawal of the extracts, blood glucose of the diabetics rats increase. It may be concluded that both Adansonia digitata and garlic may possess hypoglycemic activity which could be due to their phytochemical and mineral contents.