Over the last decade, Aryl Hydrocarbon Receptor (AHR) dragged the research community’s attention due to the associated benefits in physiology and pathology. In this study, the probable role of AHR in cancer development is discussed. The ABCG2 gene that regulates uric acid metabolism is controlled by AHR. The study noticed that the failure of AHR control over ABCG2 leads to the accumulation of uric acid, reduction of vitamin D, and hormonal imbalances that are sequentially associated with several types of cancer. Furthermore, the location of AHR in the cytoplasm and its role in the regulation of the development and differentiation of blood cells, makes it impacts on overall cells of the body, while cancer genes can be transmitted through AHR receptors in the placenta to the offspring. Overtiredness of AHR by aging, microbial, chemical, or other environmental factors escalates the risk of cancer cell growth. Consequently, immune system dysfunction is facilitated by metastasis. Meanwhile, the Tryptophan catabolism indicates the exhaustion of AHR. However, this hypothesis lacks experimental exploration for further validation.