Falciparum malaria still represents the big obstacle to communities in Sub-Sahara African countries and more concentrated efforts against COVID-19 pandemic, may influence the lives of millions of children in that malaria-endemic area. Hyperuricemia associated with plasmodium falciparum infection reflects the density of parasitemia and it may lead to kidney injury, resulting in low vitamin D production. Furthermore, hyperuricemia leads to high levels of proinflammatory cytokines counting interferon γ-induced protein, which is invested vitamin D deficiency in the development of Burkitt’s lymphoma. Experimental research is required.