The present study was undertaken to investigate the learning and memory enhancing activity of Cucurbita pepo seed extract in rats by using the ethanol induced cognitive impairment and its effects were examined by using 8-radial arm maze (8-RAM) test. For radial arm maze test all groups showed significantly (P value is< 0.0001& < 0.001) decreased in the time taken to reach the paired arm and number of entries in baited arm and non-baited arm as compared to ethanol inducing group. Therefore seed extracts of Cucurbita pepo exhibited significantly learning and memory activity in Alzheimer’s disease.