Ambrosia maritima was traditionally used in folkloric medicine to treatment of rheumatic pains, asthma, and bilharziasis. In this study the plant tested for their secondary metabolites and toxicological effects. Ambrosia maritima showed high presence of alkaloids, steroids and triterpens, moderate presence of flavonoids and tannins, and trace presence of saponins and cumarins. Biochemical and histological examination were done. Rats treated with Ambrosia maritima showed no significant change from the control, except in the ALT, significant decrease was observed. The histological examination of the plant extract showed normal appearance of most sections therefor plants seemed to be safe for oral consumption.