This study was carried out to evaluate the effect of several herbal plants, Moringa, Usira and commercially sold African Bitters on selected micro-organisms. Adequate amount of fresh plants of Moringa leaves and Usira leaves were collected from a farm in Ekpoma Also, the commercial African bitters were purchased from herbal market in Ekpoma town, Edo State. The extract was prepared by weighing out 2g of the milled powdered powdered leaf of Moringa and Usira and adding 14ml of distilled deionized water and 10ml of 70% ethanol. The agar diffusion method and ditch method were employed for the sensitivity of the extracts on the bacterial isolates. The results on agar diffusion method showed that all the organisms isolated were resistant to moringa neat and distilled water extracts but were sensitive to ethanolic extract of moringa. Also, all the organisms were also resistant to usira neat and distilled water extract. However, Candida albicans was sensitive to ethanolic extract of usira. Furthermore, none of the organisms were sensitive to African biters in all the dilutions. The results on the ditch method showed that E. coli, Candida albicans, strep were sensitive while Pseudomonas species and Klebsiella species were not sensitive. It can be concluded that the extracts of Moringa and Usira (ethanol extract) inhibited the growth of bacteria isolates in a dose dependent fashion. Hence, it can be concluded that the leaf of Moringa and Usira can be a very good source for herbal drugs especially in using ethanol as a solvents.