Novel heterogeneous catalysts development advances sustainable organic synthesis through performance enhancements and reduced environmental impact and recyclable catalyst systems. We developed biocompatible catalysts from natural and biodegradable materials for improving organic transformation capacities. Scientists developed sulfonated magnetic natural cellulose fibers for durable and eco-friendly usage as a solid acid catalyst before extensive characterization. The novel material showed its catalytic function in testing two multi-component reactions that generated biologically important heterocyclic scaffolds through bis(indolyl)methane formation as well as 3-aminoimidazo[1,2-a]pyridine derivative production. The reactions finished within short periods to yield products effectively under environmentally friendly conditions. The catalyst showed exceptional stability since an external magnet efficiently recovered it following multiple cycles where no activity decrease was observed allowing continuous usage for organic synthesis operations.