Smoke-dried fish mongers and marketers have adopted the use of organochlorines (OCPs) in the preservation of smoke-dried fish especially during storage. Although the OCPs laden fishes appear free from insect infestation, the retained residual concentrations in the fish flesh upon consumption possibly causes harm since OCPs can absorb and bio-accumulate in the blood stream and fatty tissues. This study therefore seek to quantify the residual concentrations of OCPs (DDT, endosulfan and lindane) in smoke-dried fish samples and extrapolate their toxicity effects in rabbit samples. The smoke-dried fishes were purchased from vendors, extracted and analyzed using the GCMS for OCPs (DDT, endosulfan and lindane). Thirty rabbit samples (1000 g – 1200 g) were divided into four groups (3 rabbits [control] and 9 rabbits each for DDT, endosulfan and lindane treatment groups) and three (3) concentration levels (LD50; ½ of LD50 [LD25] and ¼ of LD50 [LD12.5]) were determined based on the rabbit’s body weight and established OCPs LD50 values, then subcutaneously administered to the rabbits as a single dose. The OCPs toxicity effects on exposed rabbits were determined by analyzing the blood parameters (heamatology and serum biochemistry assay) at exposure periods (1, 3 and 7 days). The OCPs exposed rabbits exhibited varied clinical signs (itching, restlessness, jerky movements, skin scratching, salivation, increased urination and nervous signs) and their blood parameters count were significantly different (P<0.05) compared to the control (non-OCPs treated) rabbits. OCPs toxicity constitute real threat to public health considering their severe detrimental effects on the blood parameters of exposed rabbits, thus compromising their immune system and possibly leading to varied health complications. Therefore, public sensitization especially to fish mongers and marketers on the dangers of OCPs and the need to shun their use in smoke-dried fish preservation should be intensified and sustained.