Radiotherapy is a cornerstone in the treatment of Hodgkin's disease but can have long-term consequences, notably the development of secondary malignant tumors. This case study and literature review highlight the imaging characteristics, diagnostic challenges, and clinical outcomes of this late complication. The aim of this article is to underscore the role of imaging modalities in the diagnosis, characterization, and management of this rare and complex condition. We discuss the radiological findings, clinical diagnosis, and therapeutic considerations, thereby providing valuable insights into radio-induced breast cancer in Hodgkin's disease and emphasizing the importance of personalized surveillance in these high-risk patients.

Introduction: Giant cell tumour of bone (GCTB) is a locally aggressive and osteolytic tumour. The peak incidence is during the third and fourth decades of life. The majority of tumours occur in the meta-epiphyseal (end) region of the long bones. Surgical resection is the preferred treatment option, if possible but it is a tumor which always poses progressive problems. Denosumab is indicated in recurrent or unresectable GCTB. Materials & Methods: We report a series of 70 patients treated for GCT at the medical oncology department of the CPMC of Algiers in collaboration with the orthopedics department of Mustapha University Hospital between between December 2018 to December 2023. Results: 70 patients (50 women and 20 men). The sex ratio is 0.54. The average age is 22 years (11-54 years). Reason for Consultation:  Pathological fracture: n=10 -Pain: n=30 - Functional impotence: n=20 - Tumor mass: n=5 - Concept of trauma: n=5 • Stage of the disease: -Localized: n=29 -Recurrence: n=30, -Recurrence + pulmonary metastases: n=10,  Sarcomatous transformation: n=1 • Type of treatment: -Radiotherapy, n=1 -Exercised biopsy: n=10, -Curettage + cementoplasty: n=50  Exeresis with osteosynthesis material: n=8, -Amputation: n=1 • Medical treatment: Denosumab: n=45 • The number of courses with denosumab was between 6 and 55 cycles . Denosumab was administered neoadjuvantly in 10 patients, in 20 patients with reccurence disease, 15 patients in the metastatic phase  In terms of toxicity we noted hypocalcemia moderate in 3 patients. Objective Responses: 95% clinical response, 5 complete radiological responses and 10 partial responses, 20 stable patients and 9 out of 10 patients who received neoadjuvant denosumab were able to operate. Progression Free Survival is 28 months. Conclusion: GCTs are aggressive tumors with intermediate malignancy that should not be underestimated. The treatment is essentially surgical. Denosumab is indicated for both neoadjuvant and adjuvant use, it allows obtaining a clear clinical and radiological improvement.

In this case report, we present a successful combined liver-kidney transplantation (CLKT) performed on a 41-year-old female with end-stage liver and renal disease. The patient, previously undergoing liver transplantation and regular hemodialysis, underwent CLKT with a focus on specific anesthesia management strategies. Key aspects included the use of desflurane for anesthesia, balanced crystalloid solutions for fluid management, and careful monitoring of hemodynamics without intraoperative renal replacement therapy. Despite substantial intraoperative fluid and blood product administration, careful management ensured stable vital signs and acid-base balance. The patient's postoperative recovery was notable for significant improvements in liver and renal functions, demonstrated by decreased creatinine and bilirubin levels, and improved estimated glomerular filtration rate, without the need for postoperative dialysis. This case underscores the effectiveness of CLKT in patients with concurrent liver and renal dysfunction, highlighting the importance of tailored anesthesia and fluid management strategies. The report contributes to the limited literature on anesthesia in CLKT, providing insights for better outcomes in such complex surgical procedures.

Renal ectopy and hydronephrosis are two different conditions but the association of the both is very uncommon. Hydronephrosis is an abnormal enlargement of a kidney due to dilatation of the kidney calices and the kidney pelvis, it’s often associated with obstruction of the ureter that prevents normal drainage of urine to the bladder. Renal ectopy is a misplacement due to anormal migration during embryonic development. We report two patients having both conditions.

Any cancer can spread to the skin, a phenomenon typically more common in advanced stages of the disease. However, some tumors can remain clinically silent until the discovery of a cutaneous metastasis, often complicating the diagnosis of the primary tumor, especially if it's a rare tumor like breast cancer in men. It is in this context that we report a case of localized cutaneous metastasis on the scalp, without the presence of other associated clinical signs. Investigations revealed a metastatic breast carcinoma requiring extensive surgical intervention, complemented by adjuvant treatments.

Pulmonary tuberculosis is the most common cause for cavitary lung disease in India due to its endemic nature and high case burden. In spite of awareness by government organizations regarding symptoms, diagnostic modalities and treatment options for disease, Pulmonary tuberculosis management is delayed in all aspects due to the large proportion of cases receiving access to the private sector where adequate training and awareness regarding tuberculosis is missing. Constitutional symptoms of tuberculosis are not severe and fatal as well and this is the most common reason for lack of timely suspicion as commonly occurred with cardiac ailments. Constitutional symptoms in tuberculosis cases are usually managed by general practitioners in line with enteric fever, jaundice, bronchitis and pneumonia and these cases were treated accordingly. In present case report, 45-year-old female, with constitutional symptoms for six months were treated in outdoor and indoor settings by general practitioners, family physicians and other healthcare professionals with antibiotics and bronchodilators in line with enteric fever, jaundice and bronchitis with asthma on many occasions with partial response to treatment and symptoms worsening. She was referred to our center after an episode of moderate hemoptysis and we have retrospectively studied the reports and noted chronic lung cavitation in chest x-rays done a few months before which is clearly demarcated and visible in posteroanterior and lateral views. Her radiological abnormalities were never evaluated as she was never examined by a pulmonologist before our center and only x-ray was done without a confirmed diagnosis. We have documented typical cavitary lesions favoring chronic infective disease with radiological features of tuberculous cavity in HRCT chest. Her induced sputum examination for CBNAAT (Cartridge based nucleic acid amplification) MTB (mycobacterium tuberculosis) positive, Rifampicin mutation (Rpo-b) Negative. Treatment initiated with anti-tuberculosis (ATT). We have recorded near complete radiological resolution, bacteriological cure after eight months of ATT with good compliance. Pulmonary tuberculosis should be suspected early in cases with cavitating lung disease with constitutional symptoms to have a successful treatment outcome.

The prevalence of cutaneous malignancies is frequently observed in the facial region, with a notable predilection for the nasal area. The distribution of nonmelanoma skin tumors is predominantly observed in the head and neck region, accounting for approximately 75% of cases. Specifically, the nasal area is affected in approximately 30% of these instances. Basal cell carcinoma and squamous cell carcinoma represent significant clinical-surgical indications within the medical field. Moreover, the utilization of skin flaps for nasal reconstruction exhibits remarkable versatility in its various applications. The potential outcome of the reconstruction procedure is based upon various factors, including the precise location, dimensions, and depth of the defect, as well as the feasibility of accessing a suitable donor area. Just as important are the surgeon's choices regarding the materials, techniques, and approaches employed during the intervention. The innovative research conducted by Burget and Menick has brought about a paradigm shift in the field of nasal reconstruction surgery. Their pioneering contribution lies in the introduction of the concept of aesthetic subunits of the nose, in which variations in elasticity, color, contour, and skin texture are taken into account. This innovative method has significantly enhanced the precision and finesse of nasal surgical procedures, leading to remarkable advancements in the field. The unique attributes of the dermal layer that envelops the region, along with the numerous waves and projections present on its outermost layer, necessitate careful consideration in order to restore the usual natural shape and functioning. Even a small, unnoticed alteration in structure may have a significant influence on both aesthetic appeal and structural integrity. The therapeutic approach includes both functional and cosmetic considerations, with the primary objective being the mitigation of the most minimal degree of anatomical abnormality.