The estimated prevalence of glaucoma is 2.65% in people above 40 years of age. It is estimated that there are more than 60 million cases of glaucoma worldwide, the glaucoma medications are often associated with ocular adverse reactions such as dry eye, and burning or stinging sensations, and foreign body sensation. This Prospective Interventional study was conducted at eye hospitals for a period of Oct 2023 to Feb 2025.This study to find the prevalence of glaucoma and other diseases in glaucoma with comparing the cost utilization of glaucoma management. the more prominent age group affected by glaucoma was between 60-69 years, the distribution of co-morbidity in glaucoma patients were DM among the patients was 23% patients and HTN was 26% patients, the pre-existing ocular surface diseases. Dry eyes were the mostly occurred ocular surface disease in 46% patients, followed by allergic conjunctivitis 22% patients, In group 1 patients. Here g.Latanoprost was most commonly prescribed in about 40% of patients followed by g.Bimatoprost 0.03% in 28% of patients, In group 2 patients. g.Brimonidine + Timolol was most commonly prescribed in 22% of patients followed by g.Bimatoprost 0.03% in 18% of patients and 15 compares the drug cost of both groups. The mean cost of group-1 was Rs.1037± 378.9 and group 2 was Rs.521.8 ±255.7. Compared to preserved eye drops, preservative free eye drops are significantly less associated with ocular symptoms and signs of irritation and also preservative free eye drops are slightly costlier than preserved eye drops.